We work on a variety of questions involving plant/pathogen interactions, the biosynthesis of natural products, and enzymes for bioenergy applications. The common theme is the Kingdom Mycota, also known as the Fungi.
1. Fungi are the major group of plant pathogens, destroying billions of dollars of crop value every year throughout the world. Our lab specializes in studying the host-selective toxins (HSTs), which are secondary metabolites that account for the virulence and specificity of many fungal plant pathogens. Diseases that involve host-selective toxins have caused some of the world's worst plant disease epidemics, including the Southern Corn Leaf Blight epidemic of 1970 in the U.S. Our work on HSTs encompasses the enzymology and molecular genetics of their biosynthesis, understanding the molecular basis of their specificity, and their mechanisms of action. For more information see "Host selective toxins" and "Histone deacetylases" under "Research".
2. Fungi are the source of many of our most important pharmaceutical agents, including penicillin, statins, and cyclosporin. Fungi also make some of the most nefarious natural products, such as the mycotoxins (e.g., aflatoxins) and the toxins of deadly poisonous mushrooms (e.g., alpha-amanitin and phalloidin). With funding from the NIH, we are working on the molecular genetics of amatoxin and phallotoxin biosynthesis in the mushroom genera Amanita, Galerina, and Conocybe. For more information see "Biosynthesis of the Amanita toxins" under "Research".
3. Fungi are the pre-eminent recyclers in terrestrial ecosystems. They secrete an immense variety of degradative enzymes capable of converting all known biological polymers, including lignin and cellulose, to metabolizable compounds such as sugars. Fungal enzymes have many uses in food processing, industry, and biomass conversion. The use of fungal enzymes to convert lignocelluosic materials to fermentable sugars for production of "second generation" biofuels is an active area of research in our lab. Our research is supported by the DOE Great Lakes Bioenergy Research Center. For more information see "Enzymes for Bioenergy" under "Research".
I am a member of the Department of Energy Plant Research Lab (www.prl.msu.edu/), the Department of Plant Biology (www.plantbiology.msu.edu), and the DOE Great Lakes Bioenergy Research Center (glbrc.msu.edu/).
Past research areas in the Walton lab include herbicide safeners, plant cell wall biosynthesis, and the role of cell wall degrading enzymes in plant pathogenesis. See the appropriate section under "Research" for more information.
Figure explanations: Top banner: Cystidia on the edge of the gill of a species of Inocybe involved in a fatal poisoning of a young dog. Used by kind permission of Kathie Hodge, Cornell University. http://www.flickr.com/photos/34108485@N00/2829688392/
1. Conocybe albipes growing in MSU lawn. This mushroom makes the bicyclic peptide phalloidin. See "Biosynthesis of Amanita toxins" in Research.
2. Optimized proportions of 11 enzymes for release of Glc from alkaline peroxide-pretreated corn stover. Yield was 87% of total Glc. See "Enzymes for Bioenergy" in Research.
THE WALTON LAB AT MICHIGAN STATE UNIVERSITY
Apr. 18, 2013
The annual retreat (year 6!) will be returning to South Bend. Sessions of interest include fungal enzymes and marginal lands. Marginal lands and restored...
Jan. 28, 2013
Jan. 28, 2013