Structure of HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-Aeo), where
Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid. The maize Hm1
gene confers insensitivity to HC-toxin and hence resistance to C. carbonum.
Hm1
encodes HC-toxin reductase, which detoxifies HC-toxin by reducing the 8-carbonyl
group to an alcohol. More
details about HC-toxin in relation to its biosynthesis.